FAQ
[FAQ] [tag selector]
01
What is the Xelari Platform?The Xelari Platform is a comprehensive system for designing next-generation DNA/RNA-based molecular binding tools (XELAMERs).
It integrates a range of advanced computational methods – from structure prediction to complex energy calculations – into a single interface orchestrated by a language model. This enables researchers to quickly and affordably create functional binding agents with high specificity and multiple features.
02
What are XELAMERs?XELAMERs are functional aptamers (molecular binding tools) developed using the Xelari Platform.
Based on DNA/RNA structures, they are designed using rational approaches to bind to specific target proteins with high affinity and specificity. XELAMERs can be endowed with five different features, making them versatile tools for various applications in biotechnology, diagnostics, and therapy.
03
How do XELAMERs differ from antibodies and aptamers?XELAMERs combine the best properties of various binding technologies while overcoming their limitations:
Development speed: XELAMERs can be designed within hours, compared to 6-12 months for antibodies and 1-6 months for aptamers
Cost-effectiveness: Development cost is significantly lower than antibodies and aptamers
Functionality: Each XELAMER can perform up to 5 different features
Stability: XELAMERs are more stable than antibodies at various temperatures and pH conditions, and unlike most aptamers, they are not susceptible to nucleases
Reproducibility: Produced through chemical synthesis without batch-to-batch variations
Scalability: Production is simpler and more scalable
Storage: No cold chain logistics requirements like antibodies
04
Is the Platform based on artificial intelligence?The Xelari Platform is not exclusively artificial intelligence.
We use diverse computational approaches, including stochastic computations, advanced algorithms, and neural networks. AI is applied where it is most effective, such as analyzing complex relationships in simulations and as a user-friendly interface to facilitate access to the Platform.
05
Why is DNA used as a material?While DNA is primarily known as a carrier of genetic information, it also has exceptional properties as a material:
High stability
Cost-effectiveness
Ease of modification
Predictable interactions
Biocompatibility
Programmability
When used as a building material rather than for storing genetic information, DNA provides unique advantages for creating precise molecular tools with customizable features.
06
How does the Platform work for users?Working with the Platform involves several simple steps:
1. Project setup: Users create a project and describe their target (protein) and desired XELAMER features using natural language
2. Automated analysis: The system translates the user's request into structured instructions and performs the necessary computational analysis
3. Molecular design: The Platform coordinates various algorithms to model and analyze simulations during the molecular design process
4. Delivery of results: Users receive the final XELAMER design with detailed information on sequences, predicted binding properties, and functional characteristics
07
Can I communicate with the Platform in natural language?Yes, our Platform has a built-in chat interface powered by a language model that allows you to describe your requirements in natural language.
You can specify goals, refine strategies, ask technical questions, and receive real-time updates on your project's progress without needing to learn interface specifics.
08
What information do I need to provide to design a XELAMER?To design a XELAMER, you'll need to provide:
- Your target protein
(structure file or UniProtID) - Desired binding site or region
(if known) - Features you want your XELAMER to perform
- Any specific conditions
(pH, temperature, etc.)
in which your XELAMER should operate
The Platform will guide you through providing this information via a user-friendly interface.
09
How long does it take to design a XELAMER?A ready-to-use XELAMER can be designed in just 24 hours, depending on the complexity of your requirements. This is significantly faster than traditional methods such as antibody development (6-12 months) or aptamer selection (1-6 months).
10
Can I track the progress of designing a XELAMER?Yes, each project contains a timeline or progress indicator that automatically updates as various computational stages complete. You can see current tasks, remaining generation time, and details about results already obtained.
11
What computational resources are required?Thanks to our optimized AI system that integrates multiple technologies, all computations can be performed on our servers, accessible through a web interface. You don't need special equipment to access and use the Platform. You can model XELAMERs even from your smartphone.
12
What can XELAMERs be used for?XELAMERs have a wide range of applications, including:
Diagnostics:
- Cancer detection
- Pathogen identification
- Organ function assessment
- Allergy testing
- Aging biomarker determination
Therapy:
- Antidotes
- Antiviral and antipathogenic agents
- Surgical assistance
- Direct therapeutic action
- Drug delivery systems
Research:
- Protein function studies
- Cell signaling research
- Structural biology
- Development of new research methods
13
What can XELAMERs do?XELAMERs can be designed with various functional capabilities:
Modernization: Adding new properties to the target
Detection: Signaling the presence and quantity of the target
Activation: Stabilizing the active state of the target
Inhibition: Blocking the target's function
Linking: Binding the target to a surface or another molecule
14
Can XELAMERs replace antibodies in my research?In many applications, yes.
XELAMERs can be designed to have similar or better binding properties than antibodies, while offering advantages in terms of development time, cost, stability, and reproducibility. For specific research applications where antibodies are currently used, our Platform can help design appropriate XELAMERs with comparable or improved functionality.
15
Do XELAMERs work in complex biological environments?Yes, XELAMERs are designed to function in complex biological environments. During the design process, our Platform considers factors such as potential non-specific interactions, stability, and efficiency in operating conditions to ensure that XELAMERs will work effectively in your specific application environment.
16
Can XELAMERs be integrated with other technologies?Yes, XELAMERs can be designed to incorporate various modifications and functional groups that allow them to be integrated into existing approaches. This includes fluorescent labels for visualization, enzymatic domains for signal amplification, linkers for surface attachment, and other modifications to meet specific application requirements.
17
How do I get started with the Xelari Platform?To get started with the Platform, register and select a pricing plan. After your account is activated, you will be given access to the Platform where you can create projects, design XELAMERs, and interact with our team for support.
18
Is training required to use the Platform?No special training is required. The Platform is designed with a user-friendly interface that will guide you through the entire process. Natural language processing capabilities allow you to communicate with the Platform as you would with a person.
Our team is also available to provide support and assistance when needed.
19
Does Xelari conduct laboratory validation of designed XELAMERs?We have validated our technologies through a series of laboratory tests that confirm the accuracy of our computational predictions. For specific client projects, we can discuss laboratory validation options and collaboration with testing facilities to verify the effectiveness of designed XELAMERs.
20
How is intellectual property managed?When you design a XELAMER on our Platform, the primary intellectual property rights to that specific molecular design belong to you as the client.
However, Xelari retains certain rights, including the requirement that clients acknowledge Xelari as the developer of these molecules in both scientific publications and commercial applications. In some cases, Xelari also retains rights to royalties from commercial use of designed molecules. Specific intellectual property arrangements, including royalty structures where applicable, are clearly outlined in our service agreements.
21
How does the Platform ensure data security and confidentiality?We implement strict security measures to protect your data:
Secure authentication and authorization
Encryption of sensitive information
Strict access control to ensure only authorized individuals can view or modify projects
Regular security audits and updates
At the user's request, all client information can be deleted
22
Do you offer custom development services?Yes, in addition to Platform access, we offer custom development services for specialized XELAMERs and their applications. Our team can work closely with you to develop XELAMERs tailored to your specific requirements, providing expertise in molecular design, optimization, and application.
23
Is regulatory approval required for XELAMERs?XELAMERs created on the Platform are intended for research use only (RUO) and are not subject to FDA and other regulatory body oversight. If you intend to use XELAMERs for diagnostic or therapeutic applications, you will be responsible for obtaining necessary regulatory approvals. We can provide supporting information about the design and characteristics of your XELAMERs to assist in the regulatory process.
24
What current research is being conducted to improve the technology?We continuously research and improve our technologies by:
Exploring new applications in various fields
Developing new functional capabilities for XELAMERs
Enhancing our computational models and prediction algorithms
Testing and validating technological advances in laboratory settings
Accumulating and analyzing experimental data on DNA/RNA structure, properties, and dynamics
Each improvement is thoroughly tested to ensure our predictions remain accurate and practical for real-world applications.
25
How does the Xelari Platform relate to genetics and genome editing?Our Platform uses DNA/RNA as a building material, not as a carrier of genetic information. XELAMERs are designed as molecular tools that function outside genetic contexts. The project is not related to genetics or genome editing; we simply use the physical and chemical properties of nucleic acids to create functional molecular structures.
26
Can XELAMERs be produced on an industrial scale?Yes, XELAMERs are designed for easy scalability.
Unlike antibodies, which require complex biological production systems, XELAMERs can be chemically synthesized using standard oligonucleotide synthesis methods that are well-established and commercially available. This allows for stable, cost-effective production at various scales to meet your research or commercial needs.
